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Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase
Dengue is a mosquito-borne viral infection that has spread globally in recent years. Around half of the world’s population, especially in the tropics and subtropics, is at risk of infection. Every year, 50–100 million clinical cases are reported, and more than 500,000 patients develop the symptoms o...
Autores principales: | Shimizu, Hideaki, Saito, Akatsuki, Mikuni, Junko, Nakayama, Emi E., Koyama, Hiroo, Honma, Teruki, Shirouzu, Mikako, Sekine, Shun-ichi, Shioda, Tatsuo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886872/ https://www.ncbi.nlm.nih.gov/pubmed/31738758 http://dx.doi.org/10.1371/journal.pntd.0007894 |
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