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Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study

INTRODUCTION: BRCA1/2 gene mutations increase risk of breast and/or ovarian cancer and may have implications for reproductive health. Indirect biomarkers of the ovarian primordial follicle pool (anti-Müllerian hormone (AMH)) and one small study in female cadavers suggest that ovarian reserve may be...

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Detalles Bibliográficos
Autores principales: Winship, Amy Louise, Willson, Chris, Hansen, Karl R, Hutt, Karla J, Hickey, Martha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887091/
https://www.ncbi.nlm.nih.gov/pubmed/31772111
http://dx.doi.org/10.1136/bmjopen-2019-033810