Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

In preparation for bidirectional replication, the origin recognition complex (ORC) loads two MCM helicases forming a head-to-head double hexamer (DH) around DNA(1,2). How DH formation occurs is debated. Single-molecule experiments suggest a sequential mechanism whereby ORC-dependent loading of the f...

Descripción completa

Detalles Bibliográficos
Autores principales: Miller, Thomas CR, Locke, Julia, Greiwe, Julia F, Diffley, John FX, Costa, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887548/
https://www.ncbi.nlm.nih.gov/pubmed/31748745
http://dx.doi.org/10.1038/s41586-019-1768-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887548/
https://www.ncbi.nlm.nih.gov/pubmed/31748745
http://dx.doi.org/10.1038/s41586-019-1768-0

Ejemplares similares