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Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM

In preparation for bidirectional replication, the origin recognition complex (ORC) loads two MCM helicases forming a head-to-head double hexamer (DH) around DNA(1,2). How DH formation occurs is debated. Single-molecule experiments suggest a sequential mechanism whereby ORC-dependent loading of the f...

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Detalles Bibliográficos
Autores principales:	Miller, Thomas CR, Locke, Julia, Greiwe, Julia F, Diffley, John FX, Costa, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887548/ https://www.ncbi.nlm.nih.gov/pubmed/31748745 http://dx.doi.org/10.1038/s41586-019-1768-0

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