Genetic predisposition to mosaic Y chromosome loss in blood

Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism(1–5), yet our knowledge of the causes and consequences of this is limited. Using a newly developed approach, we estimate that 20% of the UK Biobank male population (N=205,011) has detectabl...

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Detalles Bibliográficos
Autores principales: Thompson, Deborah J., Genovese, Giulio, Halvardson, Jonatan, Ulirsch, Jacob C., Wright, Daniel J., Terao, Chikashi, Davidsson, Olafur B., Day, Felix R., Sulem, Patrick, Jiang, Yunxuan, Danielsson, Marcus, Davies, Hanna, Dennis, Joe, Dunlop, Malcolm G., Easton, Douglas F., Fisher, Victoria A., Zink, Florian, Houlston, Richard S., Ingelsson, Martin, Kar, Siddhartha, Kerrison, Nicola D., Kinnersley, Ben, Kristjansson, Ragnar P., Law, Philip J., Li, Rong, Loveday, Chey, Mattisson, Jonas, McCarroll, Steven A., Murakami, Yoshinori, Murray, Anna, Olszewski, Pawel, Rychlicka-Buniowska, Edyta, Scott, Robert A., Thorsteinsdottir, Unnur, Tomlinson, Ian, Torabi Moghadam, Behrooz, Turnbull, Clare, Wareham, Nicholas J., Gudbjartsson, Daniel F., Kamatani, Yoichiro, Hoffmann, Eva R., Jackson, Steve P., Stefansson, Kari, Auton, Adam, Ong, Ken K., Machiela, Mitchell J., Loh, Po-Ru, Dumanski, Jan P., Chanock, Stephen J., Forsberg, Lars A., Perry, John R. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887549/
https://www.ncbi.nlm.nih.gov/pubmed/31748747
http://dx.doi.org/10.1038/s41586-019-1765-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887549/
https://www.ncbi.nlm.nih.gov/pubmed/31748747
http://dx.doi.org/10.1038/s41586-019-1765-3

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