Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational Modeling

Inositol-requiring enzyme 1α (IRE1α) is a transmembrane dual kinase/ribonuclease protein involved in propagation of the unfolded protein response (UPR). Inositol-requiring enzyme 1α is currently being explored as a potential drug target due to the growing evidence of its role in variety of disease c...

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Detalles Bibliográficos
Autores principales: Carlesso, Antonio, Chintha, Chetan, Gorman, Adrienne M., Samali, Afshin, Eriksson, Leif A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887741/
https://www.ncbi.nlm.nih.gov/pubmed/31698846
http://dx.doi.org/10.3390/ijms20225538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887741/
https://www.ncbi.nlm.nih.gov/pubmed/31698846
http://dx.doi.org/10.3390/ijms20225538

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