A Chemical-Intervention Strategy To Circumvent Peptide Hydrolysis by d-Stereoselective Peptidases

[Image: see text] d-Stereoselective peptidases that degrade nonribosomal peptides (NRPs) were recently discovered and could have serious implications for the future of NRPs as antibiotics. Herein, we report chemical modifications that can be used to impart resistance to the d-peptidases BogQ and Tri...

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Detalles Bibliográficos
Autores principales: Bann, Samantha J., Ballantine, Ross D., McCallion, Conor E., Qian, Pei-Yuan, Li, Yong-Xin, Cochrane, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887851/
https://www.ncbi.nlm.nih.gov/pubmed/31657913
http://dx.doi.org/10.1021/acs.jmedchem.9b01078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887851/
https://www.ncbi.nlm.nih.gov/pubmed/31657913
http://dx.doi.org/10.1021/acs.jmedchem.9b01078

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