Nontranscriptional Activity of Interferon Regulatory Factor 3 Protects Mice From High‐Fat Diet‐Induced Liver Injury

Interferon regulatory factor 3 (IRF3) has both transcriptional and nontranscriptional functions. Transcriptional activity is dependent on serine phosphorylation of IRF3, while transcription‐independent IRF3‐mediated apoptosis requires ubiquitination. IRF3 also binds to inhibitor of nuclear factor ka...

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Detalles Bibliográficos
Autores principales: Sanz‐Garcia, Carlos, McMullen, Megan R., Chattopadhyay, Saurabh, Roychowdhury, Sanjoy, Sen, Ganes, Nagy, Laura E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887899/
https://www.ncbi.nlm.nih.gov/pubmed/31832571
http://dx.doi.org/10.1002/hep4.1441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887899/
https://www.ncbi.nlm.nih.gov/pubmed/31832571
http://dx.doi.org/10.1002/hep4.1441

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