Recovery in the Myogenic Program of Congenital Myotonic Dystrophy Myoblasts after Excision of the Expanded (CTG)n Repeat

The congenital form of myotonic dystrophy type 1 (cDM) is caused by the large-scale expansion of a (CTG•CAG)n repeat in DMPK and DM1-AS. The production of toxic transcripts with long trinucleotide tracts from these genes results in impairment of the myogenic differentiation capacity as cDM’s most pr...

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Detalles Bibliográficos
Autores principales: André, Laurène M., van Cruchten, Remco T.P., Willemse, Marieke, Bezstarosti, Karel, Demmers, Jeroen A.A., van Agtmaal, Ellen L., Wansink, Derick G., Wieringa, Bé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888582/
https://www.ncbi.nlm.nih.gov/pubmed/31766224
http://dx.doi.org/10.3390/ijms20225685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888582/
https://www.ncbi.nlm.nih.gov/pubmed/31766224
http://dx.doi.org/10.3390/ijms20225685

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