Cargando…

Recovery in the Myogenic Program of Congenital Myotonic Dystrophy Myoblasts after Excision of the Expanded (CTG)n Repeat

The congenital form of myotonic dystrophy type 1 (cDM) is caused by the large-scale expansion of a (CTG•CAG)n repeat in DMPK and DM1-AS. The production of toxic transcripts with long trinucleotide tracts from these genes results in impairment of the myogenic differentiation capacity as cDM’s most pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	André, Laurène M., van Cruchten, Remco T.P., Willemse, Marieke, Bezstarosti, Karel, Demmers, Jeroen A.A., van Agtmaal, Ellen L., Wansink, Derick G., Wieringa, Bé
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888582/ https://www.ncbi.nlm.nih.gov/pubmed/31766224 http://dx.doi.org/10.3390/ijms20225685

Ejemplares similares

(CTG)n repeat-mediated dysregulation of MBNL1 and MBNL2 expression during myogenesis in DM1 occurs already at the myoblast stage
por: André, Laurène M., et al.
Publicado: (2019)

CRISPR/Cas9-Induced (CTG⋅CAG)(n) Repeat Instability in the Myotonic Dystrophy Type 1 Locus: Implications for Therapeutic Genome Editing
por: van Agtmaal, Ellen L., et al.
Publicado: (2017)

Somatic CTG•CAG repeat instability in a mouse model for myotonic dystrophy type 1 is associated with changes in cell nuclearity and DNA ploidy
por: van den Broek, Walther JAA, et al.
Publicado: (2007)

Expanded CUG repeats in DMPK transcripts adopt diverse hairpin conformations without influencing the structure of the flanking sequences
por: van Cruchten, Remco T.P., et al.
Publicado: (2019)

Abnormalities in Skeletal Muscle Myogenesis, Growth, and Regeneration in Myotonic Dystrophy
por: André, Laurène M., et al.
Publicado: (2018)

Intrinsic Myogenic Potential of Skeletal Muscle-Derived Pericytes from Patients with Myotonic Dystrophy Type 1
por: Ausems, Cornelia Rosanne Maria, et al.
Publicado: (2019)

CTG-Repeat Detection in Primary Human Myoblasts of Myotonic Dystrophy Type 1
por: Hintze, Stefan, et al.
Publicado: (2021)

A comprehensive atlas of fetal splicing patterns in the brain of adult myotonic dystrophy type 1 patients
por: Degener, Max J F, et al.
Publicado: (2022)

A low absolute number of expanded transcripts is involved in myotonic dystrophy type 1 manifestation in muscle
por: Gudde, Anke E. E. G., et al.
Publicado: (2016)

Unexpected Mutations by CRISPR-Cas9 CTG Repeat Excision in Myotonic Dystrophy and Use of CRISPR Interference as an Alternative Approach
por: Ikeda, Miki, et al.
Publicado: (2020)

Impact of prematurity and the CTG repeat length on outcomes in congenital myotonic dystrophy
por: Saito, Yu, et al.
Publicado: (2020)

Brain Structural Features of Myotonic Dystrophy Type 1 and their Relationship with CTG Repeats
por: van der Plas, Ellen, et al.
Publicado: (2019)

CRISPR/Cas9-Mediated Deletion of CTG Expansions Recovers Normal Phenotype in Myogenic Cells Derived from Myotonic Dystrophy 1 Patients
por: Provenzano, Claudia, et al.
Publicado: (2017)

CRISPR/Cas Applications in Myotonic Dystrophy: Expanding Opportunities
por: Raaijmakers, Renée H.L., et al.
Publicado: (2019)

Design and Analysis of Effects of Triplet Repeat Oligonucleotides in Cell Models for Myotonic Dystrophy
por: González-Barriga, Anchel, et al.
Publicado: (2013)

Antisense transcription of the myotonic dystrophy locus yields low-abundant RNAs with and without (CAG)n repeat
por: Gudde, Anke E. E. G., et al.
Publicado: (2017)

A Tail-Anchored Myotonic Dystrophy Protein Kinase Isoform Induces Perinuclear Clustering of Mitochondria, Autophagy, and Apoptosis
por: Oude Ophuis, Ralph J. A., et al.
Publicado: (2009)

Variant repeats within the DMPK CTG expansion protect function in myotonic dystrophy type 1
por: Miller, Jacob N., et al.
Publicado: (2020)

Cell Membrane Integrity in Myotonic Dystrophy Type 1: Implications for Therapy
por: González-Barriga, Anchel, et al.
Publicado: (2015)

Relationships between grip strength, myotonia, and CTG expansion in myotonic dystrophy type 1
por: Hogrel, Jean‐Yves, et al.
Publicado: (2017)

The Need for Establishing a Universal CTG Sizing Method in Myotonic Dystrophy Type 1
por: Ballester-Lopez, Alfonsina, et al.
Publicado: (2020)

Myotonic dystrophy type 1 patient-derived iPSCs for the investigation of CTG repeat instability
por: Ueki, Junko, et al.
Publicado: (2017)

Cognitive deficits and CTG repeat expansion size in classical myotonic dystrophy type 1 (DM1)
por: Winblad, Stefan, et al.
Publicado: (2006)

Muscular myopathies other than myotonic dystrophy also associated with (CTG)(n) expansion at the DMPK locus
por: Mohan, Vasavi, et al.
Publicado: (2012)

Cortical Thickness and White Matter Integrity are Associated with CTG Expansion Size in Myotonic Dystrophy Type I
por: Yoo, Woo-Kyoung, et al.
Publicado: (2017)

Preliminary Findings on CTG Expansion Determination in Different Tissues from Patients with Myotonic Dystrophy Type 1
por: Ballester-Lopez, Alfonsina, et al.
Publicado: (2020)

Neuropathology does not Correlate with Regional Differences in the Extent of Expansion of CTG Repeats in the Brain with Myotonic Dystrophy Type 1
por: Itoh, Kyoko, et al.
Publicado: (2010)

High throughput screening for expanded CTG repeats in myotonic dystrophy type 1 using melt curve analysis
por: Butterfield, Russell J., et al.
Publicado: (2021)

Overview of the Complex Relationship between Epigenetics Markers, CTG Repeat Instability and Symptoms in Myotonic Dystrophy Type 1
por: de Pontual, Laure, et al.
Publicado: (2022)

Uncovering the Role of Hypermethylation by CTG Expansion in Myotonic Dystrophy Type 1 Using Mutant Human Embryonic Stem Cells
por: Yanovsky-Dagan, Shira, et al.
Publicado: (2015)

Analysis of CTG repeat length variation in the DMPK gene in the general population and the molecular diagnosis of myotonic dystrophy type 1 in Malaysia
por: Ambrose, Kathlin K, et al.
Publicado: (2017)

Stable Longitudinal Methylation Levels at the CpG Sites Flanking the CTG Repeat of DMPK in Patients with Myotonic Dystrophy Type 1
por: Hildonen, Mathis, et al.
Publicado: (2020)

Potassium currents in human myogenic cells from healthy and congenital myotonic dystrophy foetuses
por: Nurowska, Ewa, et al.
Publicado: (2009)

Inhibition of Postn Rescues Myogenesis Defects in Myotonic Dystrophy Type 1 Myoblast Model
por: Shen, Xiaopeng, et al.
Publicado: (2021)

Intracellular Distribution and Nuclear Activity of Antisense Oligonucleotides After Unassisted Uptake in Myoblasts and Differentiated Myotubes In Vitro
por: González-Barriga, Anchel, et al.
Publicado: (2017)

In Cis Effect of DMPK Expanded Alleles in Myotonic Dystrophy Type 1 Patients Carrying Variant Repeats at 5′ and 3′ Ends of the CTG Array
por: Visconti, Virginia Veronica, et al.
Publicado: (2023)

Myotonic Dystrophy-1 and Parkinson's Disease: Clarify the Role of CTG-repeat Size and Variants in VPS13C, SYNJ1, and DNAJC6
por: Finsterer, Josef, et al.
Publicado: (2023)

Predicting the CTG Repeat Size from a Single Spirometry Test Performed at Any Time during the Disease Course of Myotonic Dystrophy Type 1
por: Katsuse, Kazuto, et al.
Publicado: (2022)

Block or degrade? Balancing on- and off-target effects of antisense strategies against transcripts with expanded triplet repeats in DM1
por: El Boujnouni, Najoua, et al.
Publicado: (2023)

Analysis of mutational dynamics at the DMPK (CTG)(n) locus identifies saliva as a suitable DNA sample source for genetic analysis in myotonic dystrophy type 1
por: Corrales, Eyleen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_aamme2apijchm5v4ebkk76scm2