Cargando…

Enhanced Therapeutic Potential of the Secretome Released from Adipose-Derived Stem Cells by PGC-1α-Driven Upregulation of Mitochondrial Proliferation

Peroxisome proliferator activated receptor λ coactivator 1α (PGC-1α) is a potent regulator of mitochondrial biogenesis and energy metabolism. In this study, we investigated the therapeutic potential of the secretome released from the adipose-derived stem cells (ASCs) transfected with PGC-1α (PGC-sec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Jaeim, Kim, Ok-Hee, Lee, Sang Chul, Kim, Kee-Hwan, Shin, Jin Sun, Hong, Ha-Eun, Choi, Ho Joong, Kim, Say-June
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888642/ https://www.ncbi.nlm.nih.gov/pubmed/31717375 http://dx.doi.org/10.3390/ijms20225589

Ejemplares similares

Harnessing adipose-derived stem cells to release specialized secretome for the treatment of hepatitis B
por: Kim, Hee Ju, et al.
Publicado: (2021)

Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells
por: Kim, Kee-Hwan, et al.
Publicado: (2019)

A Novel Hepatic Anti-Fibrotic Strategy Utilizing the Secretome Released from Etanercept-Synthesizing Adipose-Derived Stem Cells
por: Han, Jae Hyun, et al.
Publicado: (2019)

Isolation of Secretome with Enhanced Antifibrotic Properties from miR-214-Transfected Adipose-Derived Stem Cells
por: Park, Jung Hyun, et al.
Publicado: (2019)

Determination of optimized oxygen partial pressure to maximize the liver regenerative potential of the secretome obtained from adipose-derived stem cells
por: Lee, Sang Chul, et al.
Publicado: (2017)

Lipopolysaccharide preconditioning of adipose-derived stem cells improves liver-regenerating activity of the secretome
por: Lee, Sang Chul, et al.
Publicado: (2015)

PGC‐1α is downregulated in a mouse model of obstructive cholestasis but not in a model of liver fibrosis
por: Park, Jung Hyun, et al.
Publicado: (2020)

A novel strategy to promote liver regeneration: utilization of secretome obtained from survivin-overexpressing adipose-derived stem cells
por: Kim, Cho-Hee, et al.
Publicado: (2021)

Robotic surgery enables safe and comfortable single-incision cholecystectomy: A comparison of robotic and laparoscopic approaches for single-incision surgery
por: Lee, Jaeim, et al.
Publicado: (2022)

Antioxidant action of hypoxic conditioned media from adipose-derived stem cells in the hepatic injury of expressing higher reactive oxygen species
por: Hong, Ha-Eun, et al.
Publicado: (2019)

Serum level of visfatin can reflect the severity of inflammation in patients with acute cholecystitis
por: Park, Jae Woo, et al.
Publicado: (2020)

A novel antifibrotic strategy utilizing conditioned media obtained from miR-150-transfected adipose-derived stem cells: validation of an animal model of liver fibrosis
por: Paik, Kwang Yeol, et al.
Publicado: (2020)

Combining Everolimus and Ku0063794 Promotes Apoptosis of Hepatocellular Carcinoma Cells via Reduced Autophagy Resulting from Diminished Expression of miR-4790-3p
por: Choi, Ho Joong, et al.
Publicado: (2021)

Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy
por: Lee, Sang Chul, et al.
Publicado: (2018)

Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells
por: Kim, Jong-Ok, et al.
Publicado: (2016)

Application of self-assembly peptides targeting the mitochondria as a novel treatment for sorafenib-resistant hepatocellular carcinoma cells
por: Hong, Tae Ho, et al.
Publicado: (2021)

Fungal Secretome Database: Integrated platform for annotation of fungal secretomes
por: Choi, Jaeyoung, et al.
Publicado: (2010)

IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression
por: Lee, Sang Chul, et al.
Publicado: (2015)

Does Korea's current diagnosis-related group-based reimbursement system appropriately classify appendectomy patients?
por: Kim, Kee-Hwan, et al.
Publicado: (2016)

HSP90 inhibitor 17-DMAG exerts anticancer effects against gastric cancer cells principally by altering oxidant-antioxidant balance
por: Kim, Jeong Goo, et al.
Publicado: (2017)

Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice
por: Lee, Seunghun, et al.
Publicado: (2021)

The adipose tissue stromal vascular fraction secretome enhances the proliferation but inhibits the differentiation of myoblasts
por: El-Habta, R., et al.
Publicado: (2018)

Comparative Analysis of Adipose-Derived Stromal Cells and Their Secretome for Auricular Cartilage Regeneration
por: Oh, Se-Joon, et al.
Publicado: (2020)

Therapeutic potential of adipose tissue-derived stem cells for liver failure according to the transplantation routes
por: Kim, Say-June, et al.
Publicado: (2011)

Expression of PGC1α in glioblastoma multiforme patients
por: Cho, Sang Yeon, et al.
Publicado: (2017)

Secretome of Adipose Tissue as the Key to Understanding the Endocrine Function of Adipose Tissue
por: Pogodziński, Damian, et al.
Publicado: (2022)

A Novel Way of Preventing Postoperative Pancreatic Fistula by Directly Injecting Profibrogenic Materials into the Pancreatic Parenchyma
por: Lee, Sang Chul, et al.
Publicado: (2020)

Dihydromyricetin ameliorates diet-induced obesity and promotes browning of white adipose tissue by upregulating IRF4/PGC-1α
por: Leng, Qingyang, et al.
Publicado: (2022)

D-allulose ameliorates adiposity through the AMPK-SIRT1-PGC-1α pathway in HFD-induced SD rats
por: Lee, Geum-Hwa, et al.
Publicado: (2021)

Quantifying the inflammatory secretome of human intermuscular adipose tissue
por: Kahn, Darcy, et al.
Publicado: (2022)

Role of Epicardial Adipose Tissue Secretome on Cardiovascular Diseases
por: Leo, Sara, et al.
Publicado: (2023)

Protein Kinase SGK2 Is Induced by the β(3) Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis
por: Park, Chul-Hong, et al.
Publicado: (2021)

A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue
por: Chang, Ji Suk, et al.
Publicado: (2018)

A novel single-port laparoscopic operation for colorectal cancer with transanal specimen extraction: a comparative study
por: Kim, Say-June, et al.
Publicado: (2015)

Adipose Mesenchymal Stem Cell Secretome Modulated in Hypoxia for Remodeling of Radiation-Induced Salivary Gland Damage
por: An, Hye-Young, et al.
Publicado: (2015)

Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether
por: You, Dong Do, et al.
Publicado: (2019)

PGC‐1α, a potential therapeutic target against kidney aging
por: Lee, Gayoung, et al.
Publicado: (2019)

PI3K/AKT phosphorylation activates ERRα by upregulating PGC-1α and PGC-1β in gallbladder cancer
por: Wang, Lei, et al.
Publicado: (2021)

Exofucosylation of Adipose Mesenchymal Stromal Cells Alters Their Secretome Profile
por: García-Bernal, David, et al.
Publicado: (2020)

Regional Heterogeneity of Perivascular Adipose Tissue: Morphology, Origin, and Secretome
por: Li, Xinzhi, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_snd5ppbj8q3n1dk4omihuf8l2d