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A common root for coevolution and substitution rate variability in protein sequence evolution

We introduce a simple model that describes the average occurrence of point variations in a generic protein sequence. This model is based on the idea that mutations are more likely to be fixed at sites in contact with others that have mutated in the recent past. Therefore, we extend the usual assumpt...

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Detalles Bibliográficos
Autores principales: Rizzato, Francesca, Zamuner, Stefano, Pagnani, Andrea, Laio, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888882/
https://www.ncbi.nlm.nih.gov/pubmed/31792239
http://dx.doi.org/10.1038/s41598-019-53958-w