TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity

Regulatory T (T reg) cells are required for the maintenance of immune homeostasis. Both TGF-β signaling and epigenetic modifications are important for Foxp3 induction, but how TGF-β signaling participates in the epigenetic regulation of Foxp3 remains largely unknown. Here we showed that T cell–speci...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Xiang, Cui, Yu, Feng, Haiyun, Liu, Haifeng, Liu, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888975/
https://www.ncbi.nlm.nih.gov/pubmed/31515281
http://dx.doi.org/10.1084/jem.20190550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888975/
https://www.ncbi.nlm.nih.gov/pubmed/31515281
http://dx.doi.org/10.1084/jem.20190550

Ejemplares similares