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TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity

Regulatory T (T reg) cells are required for the maintenance of immune homeostasis. Both TGF-β signaling and epigenetic modifications are important for Foxp3 induction, but how TGF-β signaling participates in the epigenetic regulation of Foxp3 remains largely unknown. Here we showed that T cell–speci...

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Detalles Bibliográficos
Autores principales:	Sun, Xiang, Cui, Yu, Feng, Haiyun, Liu, Haifeng, Liu, Xiaolong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888975/ https://www.ncbi.nlm.nih.gov/pubmed/31515281 http://dx.doi.org/10.1084/jem.20190550

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