Cargando…

TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity

Regulatory T (T reg) cells are required for the maintenance of immune homeostasis. Both TGF-β signaling and epigenetic modifications are important for Foxp3 induction, but how TGF-β signaling participates in the epigenetic regulation of Foxp3 remains largely unknown. Here we showed that T cell–speci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Xiang, Cui, Yu, Feng, Haiyun, Liu, Haifeng, Liu, Xiaolong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888975/ https://www.ncbi.nlm.nih.gov/pubmed/31515281 http://dx.doi.org/10.1084/jem.20190550

Ejemplares similares

Differential regulation of the REGγ–proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells
por: Ali, Amjad, et al.
Publicado: (2013)

Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation
por: Freudenberg, Kristin, et al.
Publicado: (2018)

Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) T(reg) cells are a source of tumour-associated T(reg) cells
por: Downs-Canner, Stephanie, et al.
Publicado: (2017)

FoxP3 in T(reg) cell biology: a molecular and structural perspective
por: Deng, G., et al.
Publicado: (2019)

A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3(+) T(REG) differentiation
por: Mamontov, Polina, et al.
Publicado: (2019)

Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance
por: Vaughan, Robert M, et al.
Publicado: (2018)

FOXP3 expression is modulated by TGF-β1/NOTCH1 pathway in human melanoma
por: Skarmoutsou, Eva, et al.
Publicado: (2018)

Interleukin 4 inhibits TGF-β-induced-Foxp3(+)T cells and generates, in combination with TGF-β, Foxp3(−) effector T cells that produce interleukins 9 and 10
por: Dardalhon, Valérie, et al.
Publicado: (2008)

Mechanisms of human FoxP3(+) T(reg) cell development and function in health and disease
por: Attias, M., et al.
Publicado: (2019)

The Growing Complexity of UHRF1-Mediated Maintenance DNA Methylation
por: Xie, Si, et al.
Publicado: (2018)

CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4(+ )T(reg )cells
por: Liu, Tie, et al.
Publicado: (2009)

Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression
por: Xu, Lili, et al.
Publicado: (2010)

Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling
por: Li, Hongda, et al.
Publicado: (2021)

FoxP3 Interacts with Linker Histone H1.5 to Modulate Gene Expression and Program T(reg) Cell Activity
por: Mackey-Cushman, Stephanie L., et al.
Publicado: (2011)

Involvement of PGC7 and UHRF1 in the regulation of DNA methylation of the IG-DMR in the imprinted Dlk1-Dio3 locus : PGC7 and UHRF1 regulats IG-DMR methylation
por: Yu, Mengying, et al.
Publicado: (2022)

Methylated-UHRF1 and PARP1 interaction is critical for homologous recombination
por: Hahm, Ja Young, et al.
Publicado: (2020)

Uhrf1 governs the proliferation and differentiation of muscle satellite cells
por: Sakai, Hiroshi, et al.
Publicado: (2022)

Downregulation of FOXP2 promotes breast cancer migration and invasion through TGFβ/SMAD signaling pathway
por: Chen, Meng-Ting, et al.
Publicado: (2018)

Association of UHRF1 with H3K9 methylation directs the maintenance of DNA methylation
por: Rothbart, Scott B., et al.
Publicado: (2012)

Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos
por: Maenohara, Shoji, et al.
Publicado: (2017)

FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway
por: Shi, Jie-Yi, et al.
Publicado: (2017)

Alternative splicing and allosteric regulation modulate the chromatin binding of UHRF1
por: Tauber, Maria, et al.
Publicado: (2020)

UHRF1 Induces Metastasis in Thyroid Cancer
por: Kuang, Bo-Hua, et al.
Publicado: (2022)

Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
por: Fang, Jian, et al.
Publicado: (2016)

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4(+) T reg cells
por: Liu, Weihong, et al.
Publicado: (2006)

SET8 prevents excessive DNA methylation by methylation-mediated degradation of UHRF1 and DNMT1
por: Zhang, Huifang, et al.
Publicado: (2019)

Methylation of UHRF1 by SET7 is essential for DNA double-strand break repair
por: Hahm, Ja Young, et al.
Publicado: (2019)

TCR signals fuel T(reg) cells
por: Drees, Christoph, et al.
Publicado: (2015)

CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface
por: Yakymovych, Ihor, et al.
Publicado: (2015)

PAR1 Scaffolds TGFβRII to Downregulate TGF-β Signaling and Activate ESC Differentiation to Endothelial Cells
por: Gong, Haixia, et al.
Publicado: (2016)

Galectin-8 promotes regulatory T cell differentiation by modulating IL-2 and TGFβ signaling
por: Sampson, James F., et al.
Publicado: (2015)

Induction of stable human FOXP3(+) Tregs by a parasite‐derived TGF‐β mimic
por: Cook, Laura, et al.
Publicado: (2021)

Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis
por: Zhu, Mingchen, et al.
Publicado: (2015)

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1
por: Harrison, Joseph S, et al.
Publicado: (2016)

Effects of panax notoginseng saponins on the osteogenic differentiation of rabbit bone mesenchymal stem cells through TGF-β1 signaling pathway
por: Wang, Yan, et al.
Publicado: (2016)

Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating T(reg) cells
por: Feng, M., et al.
Publicado: (2019)

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3(+) T reg cells
por: Weiss, Jonathan M., et al.
Publicado: (2012)

Foxp3(+) T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8(+) T cell response
por: Stockenhuber, Krista, et al.
Publicado: (2018)

Commensal epitopes drive differentiation of colonic T(regs)
por: Kuczma, Michal P., et al.
Publicado: (2020)

Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(−)Foxp3(+) T cells
por: Polanczyk, Magdalena J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_v63856l9hn62ethi6g77omufvn