Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR

The role of lipids in inflammasome activation remains underappreciated. The phospholipid, platelet-activating factor (PAF), exerts multiple physiological functions by binding to a G protein–coupled seven-transmembrane receptor (PAFR). PAF is associated with a number of inflammatory disorders, yet th...

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Detalles Bibliográficos
Autores principales: Deng, Meng, Guo, Haitao, Tam, Jason W., Johnson, Brandon M., Brickey, W. June, New, James S., Lenox, Austin, Shi, Hexin, Golenbock, Douglas T., Koller, Beverly H., McKinnon, Karen P., Beutler, Bruce, Ting, Jenny P.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888982/
https://www.ncbi.nlm.nih.gov/pubmed/31558613
http://dx.doi.org/10.1084/jem.20190111

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