A novel inhibitor of MDM2 oncogene blocks metastasis of hepatocellular carcinoma and overcomes chemoresistance

Overexpression of the MDM2 oncogene and mutations in the p53 tumor suppressor commonly occur in hepatocellular carcinoma (HCC) and are associated with increased mortality due to this disease. Inhibiting MDM2 has been demonstrated to be a valid approach for the treatment of HCC. However, most of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Wei, Hu, Bo, Qin, Jiang-Jiang, Cheng, Jian-Wen, Li, Xin, Rajaei, Mehrdad, Fan, Jia, Yang, Xin-Rong, Zhang, Ruiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889017/
https://www.ncbi.nlm.nih.gov/pubmed/31832522
http://dx.doi.org/10.1016/j.gendis.2019.06.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889017/
https://www.ncbi.nlm.nih.gov/pubmed/31832522
http://dx.doi.org/10.1016/j.gendis.2019.06.001

Ejemplares similares