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Molecular and structural insights into an asymmetric proteolytic complex (ClpP1P2) from Mycobacterium smegmatis

The ClpP protease is found in all kingdoms of life, from bacteria to humans. In general, this protease forms a homo-oligomeric complex composed of 14 identical subunits, which associates with its cognate ATPase in a symmetrical manner. Here we show that, in contrast to this general architecture, the...

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Detalles Bibliográficos
Autores principales: Nagpal, Jyotsna, Paxman, Jason J., Zammit, Jessica E., Thomas, Adam A., Truscott, Kaye N., Heras, Begoña, Dougan, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889138/
https://www.ncbi.nlm.nih.gov/pubmed/31792243
http://dx.doi.org/10.1038/s41598-019-53736-8