Assessment of TP53 lesions for p53 system functionality and drug resistance in multiple myeloma using an isogenic cell line model

Recent advances in molecular diagnostics have shown that lesions affecting both copies of the gene for tumor suppressor protein 53 (TP53) count among the most powerful predictors for high-risk disease in multiple myeloma (MM). However, the functional relevance and potential therapeutic implications...

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Detalles Bibliográficos
Autores principales: Munawar, Umair, Roth, Markus, Barrio, Santiago, Wajant, Harald, Siegmund, Daniela, Bargou, Ralf C., Kortüm, K. Martin, Stühmer, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889167/
https://www.ncbi.nlm.nih.gov/pubmed/31792264
http://dx.doi.org/10.1038/s41598-019-54407-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889167/
https://www.ncbi.nlm.nih.gov/pubmed/31792264
http://dx.doi.org/10.1038/s41598-019-54407-4

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