A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis

BACKGROUND: Cancer arises through accumulation of somatically acquired genetic mutations. An important question is to delineate the temporal order of somatic mutations during carcinogenesis, which contributes to better understanding of cancer biology and facilitates identification of new therapeutic...

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Detalles Bibliográficos
Autores principales: Wang, Menghan, Yu, Tianxin, Liu, Jinpeng, Chen, Li, Stromberg, Arnold J., Villano, John L., Arnold, Susanne M., Liu, Chunming, Wang, Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889196/
https://www.ncbi.nlm.nih.gov/pubmed/31791231
http://dx.doi.org/10.1186/s12859-019-3218-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889196/
https://www.ncbi.nlm.nih.gov/pubmed/31791231
http://dx.doi.org/10.1186/s12859-019-3218-2

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