Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype

BACKGROUND: Glioblastoma (GBM) is the most lethal and aggressive malignant primary brain tumor in adults. After surgical resection of the tumor, the patient typically should be subjected to chemotherapy (temozolomide, TMZ) and concomitant radiotherapy. Since the TMZ treatment does not lead to comple...

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Detalles Bibliográficos
Autores principales: Stazi, Giulia, Taglieri, Ludovica, Nicolai, Alice, Romanelli, Annalisa, Fioravanti, Rossella, Morrone, Stefania, Sabatino, Manuela, Ragno, Rino, Taurone, Samanta, Nebbioso, Marcella, Carletti, Raffaella, Artico, Marco, Valente, Sergio, Scarpa, Susanna, Mai, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889222/
https://www.ncbi.nlm.nih.gov/pubmed/31791385
http://dx.doi.org/10.1186/s13148-019-0763-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889222/
https://www.ncbi.nlm.nih.gov/pubmed/31791385
http://dx.doi.org/10.1186/s13148-019-0763-5

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