Impact of Q-Griffithsin anti-HIV microbicide gel in non-human primates: In situ analyses of epithelial and immune cell markers in rectal mucosa

Natural-product derived lectins can function as potent viral inhibitors with minimal toxicity as shown in vitro and in small animal models. We here assessed the effect of rectal application of an anti-HIV lectin-based microbicide Q-Griffithsin (Q-GRFT) in rectal tissue samples from rhesus macaques....

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Detalles Bibliográficos
Autores principales: Günaydın, Gökçe, Edfeldt, Gabriella, Garber, David A., Asghar, Muhammad, Noȅl-Romas, Laura, Burgener, Adam, Wählby, Carolina, Wang, Lin, Rohan, Lisa C., Guenthner, Patricia, Mitchell, James, Matoba, Nobuyuki, McNicholl, Janet M., Palmer, Kenneth E., Tjernlund, Annelie, Broliden, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889265/
https://www.ncbi.nlm.nih.gov/pubmed/31792342
http://dx.doi.org/10.1038/s41598-019-54493-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889265/
https://www.ncbi.nlm.nih.gov/pubmed/31792342
http://dx.doi.org/10.1038/s41598-019-54493-4

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