Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer

BACKGROUND: Tumours rapidly ferment glucose to lactic acid even in the presence of oxygen, and coupling high glycolysis with poor perfusion leads to extracellular acidification. We hypothesise that acidity, independent from lactate, can augment the pro-tumour phenotype of macrophages. METHODS: We an...

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Detalles Bibliográficos
Autores principales: El-Kenawi, Asmaa, Gatenbee, Chandler, Robertson-Tessi, Mark, Bravo, Rafael, Dhillon, Jasreman, Balagurunathan, Yoganand, Berglund, Anders, Vishvakarma, Naveen, Ibrahim-Hashim, Arig, Choi, Jung, Luddy, Kimberly, Gatenby, Robert, Pilon-Thomas, Shari, Anderson, Alexander, Ruffell, Brian, Gillies, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889319/
https://www.ncbi.nlm.nih.gov/pubmed/31417189
http://dx.doi.org/10.1038/s41416-019-0542-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889319/
https://www.ncbi.nlm.nih.gov/pubmed/31417189
http://dx.doi.org/10.1038/s41416-019-0542-2

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