The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site

BACKGROUND: Malaria kills over 400,000 people each year and nearly half the world’s population live in at-risk areas. Progress against malaria has recently stalled, highlighting the need for developing novel therapeutics. The parasite haemoglobin degradation pathway, active in the blood stage of the...

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Detalles Bibliográficos
Autores principales: Machin, Jonathan M., Kantsadi, Anastassia L., Vakonakis, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889325/
https://www.ncbi.nlm.nih.gov/pubmed/31791339
http://dx.doi.org/10.1186/s12936-019-3043-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889325/
https://www.ncbi.nlm.nih.gov/pubmed/31791339
http://dx.doi.org/10.1186/s12936-019-3043-0

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