Molecular mechanisms of the juvenile form of Batten disease: important role of MAPK signaling pathways (ERK1/ERK2, JNK and p38) in pathogenesis of the malady

BACKGROUND: Mutations in the CLN3 gene lead to so far an incurable juvenile-onset neuronal ceroid lipofuscinosis (JNCL) or Batten disease that starts at the age of 4–6 years with a progressive retinopathy leading to blindness. Motor disturbances, epilepsy and dementia manifest during several followi...

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Detalles Bibliográficos
Autores principales: Shematorova, Elena K., Shpakovski, Dmitry G., Chernysheva, Anna D., Shpakovski, George V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889328/
https://www.ncbi.nlm.nih.gov/pubmed/30621751
http://dx.doi.org/10.1186/s13062-018-0212-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889328/
https://www.ncbi.nlm.nih.gov/pubmed/30621751
http://dx.doi.org/10.1186/s13062-018-0212-y

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