Cargando…

Thawed Mesenchymal Stem Cell Product Shows Comparable Immunomodulatory Potency to Cultured Cells In Vitro and in Polymicrobial Septic Animals

Mesenchymal stem cells (MSCs) have been shown to exert immunomodulatory effects in both acute and chronic diseases. In acute inflammatory conditions like sepsis, cell therapy must be administered within hours of diagnosis, requiring “off-the-shelf” cryopreserved allogeneic cell products. However, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Yuan, Salkhordeh, Mahmoud, Wang, Jia-Pey, McRae, Andrea, Souza-Moreira, Luciana, McIntyre, Lauralyn, Stewart, Duncan J., Mei, Shirley H. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889371/ https://www.ncbi.nlm.nih.gov/pubmed/31792313 http://dx.doi.org/10.1038/s41598-019-54462-x

Ejemplares similares

Comparison of freshly cultured versus freshly thawed (cryopreserved) mesenchymal stem cells in preclinical in vivo models of inflammation: a protocol for a preclinical systematic review and meta-analysis
por: Dave, Chintan, et al.
Publicado: (2020)

Poly(I:C) enhances mesenchymal stem cell control of myeloid cells from COVID-19 patients
por: Souza-Moreira, Luciana, et al.
Publicado: (2022)

Mesenchymal stem cells induce dynamic immunomodulation of airway and systemic immune cells in vivo but do not improve survival for mice with H1N1 virus-induced acute lung injury
por: Tan, Yuan, et al.
Publicado: (2023)

Comparison of freshly cultured versus cryopreserved mesenchymal stem cells in animal models of inflammation: A pre-clinical systematic review
por: Dave, Chintan, et al.
Publicado: (2022)

Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients*
por: Schlosser, Kenny, et al.
Publicado: (2019)

A survey of Canadian intensivists' resuscitation practices in early septic shock
por: McIntyre, Lauralyn A, et al.
Publicado: (2007)

Optimizing an immunomodulatory potency assay for Mesenchymal Stromal Cell
por: Hansen, Stine Bangsgaard, et al.
Publicado: (2022)

The conundrum of persistent inappropriate use of frozen plasma
por: Tinmouth, Alan T, et al.
Publicado: (2011)

A model of porcine polymicrobial septic shock
por: Zurek-Leffers, Finnja Marie, et al.
Publicado: (2023)

Abstract 23 A First Insight into the Validity of Post-Thaw Cell Recovery, Viability, and Potency Over Time
por: Liu, Lin, et al.
Publicado: (2022)

Metabolomics Analysis of Mesenchymal Stem Cell (MSC) Therapy in a Phase I Clinical Trial of Septic Shock: An Exploratory Study
por: Banoei, Mohammad M., et al.
Publicado: (2023)

Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis
por: Lee, Wook-Bin, et al.
Publicado: (2017)

Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis
por: Yeh, Jih-Chao, et al.
Publicado: (2023)

High circulating angiopoietin-2 levels exacerbate pulmonary inflammation but not vascular leak or mortality in endotoxin-induced lung injury in mice
por: Schlosser, Kenny, et al.
Publicado: (2018)

An In Vitro Potency Assay for Monitoring the Immunomodulatory Potential of Stromal Cell-Derived Extracellular Vesicles
por: Pachler, Karin, et al.
Publicado: (2017)

Design, production and immunomodulatory potency of a novel allergen bioparticle
por: Gomord, Véronique, et al.
Publicado: (2020)

Lack of elevation in plasma levels of pro-inflammatory cytokines in common rodent models of pulmonary arterial hypertension: questions of construct validity for human patients
por: Schlosser, Kenny, et al.
Publicado: (2017)

Immunomodulatory Effect of Doxycycline Ameliorates Systemic and Pulmonary Inflammation in a Murine Polymicrobial Sepsis Model
por: Patel, Anasuya, et al.
Publicado: (2020)

Customized Internal Reference Controls for Improved Assessment of Circulating MicroRNAs in Disease
por: Schlosser, Kenny, et al.
Publicado: (2015)

Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials
por: Lalu, Manoj M., et al.
Publicado: (2012)

Choice of crystalloid fluid in the treatment of hyperglycemic emergencies: a systematic review protocol
por: Gershkovich, Benjamin, et al.
Publicado: (2019)

Methyl Sulfone Blocked Multiple Hypoxia- and Non-Hypoxia-Induced Metastatic Targets in Breast Cancer Cells and Melanoma Cells
por: Caron, Joan McIntyre, et al.
Publicado: (2015)

Red blood cell transfusion and mortality effect in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis protocol
por: English, Shane W, et al.
Publicado: (2015)

Interventions to prevent hemodynamic instability during renal replacement therapy for acute kidney injury: a systematic review protocol
por: Douvris, Adrianna, et al.
Publicado: (2017)

How well do critical care audit and feedback interventions adhere to best practice? Development and application of the REFLECT-52 evaluation tool
por: Foster, Madison, et al.
Publicado: (2021)

Immunomodulatory effects of anaesthetic sevoflurane in septic mouse model
por: Liu, Dengke, et al.
Publicado: (2021)

Audit and feedback to improve laboratory test and transfusion ordering in critical care: a systematic review
por: Foster, Madison, et al.
Publicado: (2020)

Polymicrobial Diseases
por: Haverkos, Harry W.
Publicado: (2003)

Spred2-deficiecy Protects Mice from Polymicrobial Septic Peritonitis by Enhancing Inflammation and Bacterial Clearance
por: Itakura, Junya, et al.
Publicado: (2017)

Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial
por: Maiden, Matthew J., et al.
Publicado: (2018)

Haemoperfusion should only be used for COVID-19 in the context of randomized trials
por: Clark, Edward G., et al.
Publicado: (2020)

Efficacy and safety of regenerative cell therapy for pulmonary arterial hypertension in animal models: a preclinical systematic review protocol
por: Suen, Colin M., et al.
Publicado: (2016)

Anti-proliferative and immunomodulatory potencies of cinnamon oil on Ehrlich ascites carcinoma bearing mice
por: Morsi, Dalia S., et al.
Publicado: (2022)

Tactile Motion Adaptation Reduces Perceived Speed but Shows No Evidence of Direction Sensitivity
por: McIntyre, Sarah, et al.
Publicado: (2012)

392. Epidemiology and Treatment Outcome of Gram-Negative Polymicrobial, Gram-Positive Polymicrobial and Mixed Polymicrobial Prosthetic Joint Infection
por: Hooshmand, Babak, et al.
Publicado: (2019)

Immunomodulatory Effects of Saccharomyces cerevisiae Fermentation Product Supplementation on Immune Gene Expression and Lymphocyte Distribution in Immune Organs in Broilers
por: Chou, Wen K., et al.
Publicado: (2017)

Thawed cryopreserved synovial mesenchymal stem cells show comparable effects to cultured cells in the inhibition of osteoarthritis progression in rats
por: Horiuchi, Kiyotaka, et al.
Publicado: (2021)

Polymicrobial infection of the oral mucosa after hematopoietic stem cell transplantation. Case report
por: Ramos, Gabriela de Assis, et al.
Publicado: (2019)

Effect of prenotification on the response rate of a postal survey of emergency physicians: a randomised, controlled, assessor-blind trial
por: Hickey, Michael, et al.
Publicado: (2021)

Impact of Graded Passive Cycling on Hemodynamics, Cerebral Blood Flow, and Cardiac Function in Septic ICU Patients
por: Chen, Jennifer, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_hootepants6jc1uoddfj53vp07