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Multiple selective sweeps of ancient polymorphisms in and around LTα located in the MHC class III region on chromosome 6

BACKGROUND: Lymphotoxin-α (LTα), located in the Major Histocompatibility Complex (MHC) class III region on chromosome 6, encodes a cytotoxic protein that mediates a variety of antiviral responses among other biological functions. Furthermore, several genotypes at this gene have been implicated in th...

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Detalles Bibliográficos
Autores principales: Campbell, Michael C., Ashong, Bryan, Teng, Shaolei, Harvey, Jayla, Cross, Christopher N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889576/
https://www.ncbi.nlm.nih.gov/pubmed/31791241
http://dx.doi.org/10.1186/s12862-019-1516-y