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Deciphering the Gene Regulatory Landscape Encoded in DNA Biophysical Features

Gene regulation in higher organisms involves a sophisticated interplay between genetic and epigenetic mechanisms. Despite advances, the logic in selective usage of certain genomic regions as regulatory elements remains unclear. Here we show that the inherent biophysical properties of the DNA encode...

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Detalles Bibliográficos
Autores principales: Pataskar, Abhijeet, Vanderlinden, Willem, Emmerig, Johannes, Singh, Aditi, Lipfert, Jan, Tiwari, Vijay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889597/
https://www.ncbi.nlm.nih.gov/pubmed/31731201
http://dx.doi.org/10.1016/j.isci.2019.10.055