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Alternative splicing of UCP1 by non-cell-autonomous action of PEMT

OBJECTIVE: Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking PEMT (PEMTKO) are cold-intolerant when fed a high-fat diet (HFD) due t...

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Detalles Bibliográficos
Autores principales: Johnson, Jordan M., Verkerke, Anthony R.P., Maschek, J. Alan, Ferrara, Patrick J., Lin, Chien-Te, Kew, Kimberly A., Neufer, P. Darrell, Lodhi, Irfan J., Cox, James E., Funai, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889607/
https://www.ncbi.nlm.nih.gov/pubmed/31918922
http://dx.doi.org/10.1016/j.molmet.2019.10.007