Usefulness of Bnet, a Simple Linear Metric in Discerning Torsades De Pointes Risks in 28 CiPA Drugs

The Comprehensive in vitro Proarrhythmia Assay (CiPA) project suggested the torsade metric score (TMS) which requires substantial computing resources as a useful biomarker to predict proarrhythmic risk from human ether-à-go-go–related gene (hERG) and a few other ion channel block data. The TMS was u...

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Detalles Bibliográficos
Autores principales: Han, Sungpil, Han, Seunghoon, Kim, Ki-Suk, Lee, Hyang-Ae, Yim, Dong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889857/
https://www.ncbi.nlm.nih.gov/pubmed/31849669
http://dx.doi.org/10.3389/fphar.2019.01419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889857/
https://www.ncbi.nlm.nih.gov/pubmed/31849669
http://dx.doi.org/10.3389/fphar.2019.01419

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