The KLDpT activation loop motif is critical for MARK kinase activity

MAP/microtubule-affinity regulating kinases (MARK1-4) are members of the AMPK family of Ser/Thr-specific kinases, which phosphorylate substrates at consensus LXRXXSXXXL motifs. Within microtubule-associated proteins, MARKs also mediate phosphorylation of variant KXGS or ζXKXGSXXNΨ motifs, interferin...

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Detalles Bibliográficos
Autores principales: Sonntag, Tim, Moresco, James J., Yates, John R., Montminy, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890249/
https://www.ncbi.nlm.nih.gov/pubmed/31794565
http://dx.doi.org/10.1371/journal.pone.0225727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890249/
https://www.ncbi.nlm.nih.gov/pubmed/31794565
http://dx.doi.org/10.1371/journal.pone.0225727

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