Apremilast Normalizes Gene Expression of Inflammatory Mediators in Human Keratinocytes and Reduces Antigen-Induced Atopic Dermatitis in Mice

BACKGROUND: Apremilast, an oral phosphodiesterase (PDE) 4 inhibitor, has demonstrated efficacy in psoriasis, while its efficacy in atopic dermatitis (AD) was found to be modest. AD is a chronic inflammatory skin disease associated with activation of T helper (Th) 2 and Th17 immunity and a compromise...

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Detalles Bibliográficos
Autores principales: Schafer, Peter H., Adams, Mary, Horan, Gerald, Truzzi, Francesca, Marconi, Alessandra, Pincelli, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890576/
https://www.ncbi.nlm.nih.gov/pubmed/31598889
http://dx.doi.org/10.1007/s40268-019-00284-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890576/
https://www.ncbi.nlm.nih.gov/pubmed/31598889
http://dx.doi.org/10.1007/s40268-019-00284-1

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