A Bottom-Up Whole-Body Physiologically Based Pharmacokinetic Model to Mechanistically Predict Tissue Distribution and the Rate of Subcutaneous Absorption of Therapeutic Proteins

The ability to predict subcutaneous (SC) absorption rate and tissue distribution of therapeutic proteins (TPs) using a bottom-up approach is highly desirable early in the drug development process prior to clinical data being available. A whole-body physiologically based pharmacokinetic (PBPK) model,...

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Detalles Bibliográficos
Autores principales: Gill, Katherine L., Gardner, Iain, Li, Linzhong, Jamei, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890583/
https://www.ncbi.nlm.nih.gov/pubmed/26408308
http://dx.doi.org/10.1208/s12248-015-9819-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890583/
https://www.ncbi.nlm.nih.gov/pubmed/26408308
http://dx.doi.org/10.1208/s12248-015-9819-4

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