Loss of the serine protease HTRA1 impairs smooth muscle cells maturation

Vascular smooth muscle cell (VSMC) dysfunction is a hallmark of small vessel disease, a common cause of stroke and dementia. Two of the most frequently mutated genes in familial small vessel disease are HTRA1 and NOTCH3. The protease HTRA1 cleaves the NOTCH3 ligand JAG1 implying a mechanistic link b...

Descripción completa

Detalles Bibliográficos
Autores principales: Klose, Ralph, Prinz, Alexander, Tetzlaff, Fabian, Weis, Eva-Maria, Moll, Iris, Rodriguez-Vita, Juan, Oka, Chio, Korff, Thomas, Fischer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890777/
https://www.ncbi.nlm.nih.gov/pubmed/31796853
http://dx.doi.org/10.1038/s41598-019-54807-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890777/
https://www.ncbi.nlm.nih.gov/pubmed/31796853
http://dx.doi.org/10.1038/s41598-019-54807-6

Ejemplares similares