Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance

Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic changes in antifungal susceptibility, which a...

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Detalles Bibliográficos
Autores principales: Hope, William, Stone, Neil R. H., Johnson, Adam, McEntee, Laura, Farrington, Nicola, Santoro-Castelazo, Anahi, Liu, Xuan, Lucaci, Anita, Hughes, Margaret, Oliver, Jason D., Giamberardino, Charles, Mfinanga, Sayoki, Harrison, Thomas S., Perfect, John R., Bicanic, Tihana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890991/
https://www.ncbi.nlm.nih.gov/pubmed/31796539
http://dx.doi.org/10.1128/mBio.02575-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890991/
https://www.ncbi.nlm.nih.gov/pubmed/31796539
http://dx.doi.org/10.1128/mBio.02575-19

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