Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

LRRK2 kinase mutations cause familial Parkinson’s disease and increased phosphorylation of a subset of Rab GTPases. Rab29 recruits LRRK2 to the trans-Golgi and activates it there, yet some of LRRK2’s major Rab substrates are not on the Golgi. We sought to characterize the cell biology of LRRK2 activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Gomez, Rachel C., Wawro, Paulina, Lis, Pawel, Alessi, Dario R., Pfeffer, Suzanne R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891090/
https://www.ncbi.nlm.nih.gov/pubmed/31624137
http://dx.doi.org/10.1083/jcb.201902184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891090/
https://www.ncbi.nlm.nih.gov/pubmed/31624137
http://dx.doi.org/10.1083/jcb.201902184

Ejemplares similares