Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate

Mitochondrial stress contributes to a range of neurological diseases. Mitonuclear signaling pathways triggered by mitochondrial stress remodel cellular physiology and metabolism. How these signaling mechanisms contribute to neuronal dysfunction and disease is poorly understood. We find that mitochon...

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Detalles Bibliográficos
Autores principales: Hunt, Rachel J., Granat, Lucy, McElroy, Gregory S., Ranganathan, Ramya, Chandel, Navdeep S., Bateman, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891100/
https://www.ncbi.nlm.nih.gov/pubmed/31645461
http://dx.doi.org/10.1083/jcb.201904148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891100/
https://www.ncbi.nlm.nih.gov/pubmed/31645461
http://dx.doi.org/10.1083/jcb.201904148

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