The Synthesis, Characterization, Cytotoxic Activity Assessment and Structure-Activity Relationship of 4-Aryl-6-(2,5-dichlorothiophen-3-yl)-2-methoxypyridine-3-carbonitriles

A series of 2-methoxypyridine-3-carbonitrile (5a–i)-bearing aryl substituents were successfully synthesized in good yields by the condensation of chalcones (4a–i) with malononitrile in basic medium. The condensation process, in most cases, offers a route to a variety of methoxypyridine derivatives (...

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Detalles Bibliográficos
Autores principales: Al-Refai, Mahmoud, Ibrahim, Mohammad M., Nurul Azmi, Mohamad, Osman, Hasnah, Abu Bakar, Mohamad Hafizi, Geyer, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891325/
https://www.ncbi.nlm.nih.gov/pubmed/31717690
http://dx.doi.org/10.3390/molecules24224072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891325/
https://www.ncbi.nlm.nih.gov/pubmed/31717690
http://dx.doi.org/10.3390/molecules24224072

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