Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways

Voltage-gated sodium channels (Na(V)s) are a key determinant of neuronal signalling. Neurotoxins from diverse taxa that selectively activate or inhibit Na(V) channels have helped unravel the role of Na(V) channels in diseases, including chronic pain. Spider venoms contain the most diverse array of i...

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Detalles Bibliográficos
Autores principales: Dongol, Yashad, Cardoso, Fernanda C., Lewis, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891507/
https://www.ncbi.nlm.nih.gov/pubmed/31671792
http://dx.doi.org/10.3390/toxins11110626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891507/
https://www.ncbi.nlm.nih.gov/pubmed/31671792
http://dx.doi.org/10.3390/toxins11110626

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