Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction

Human carboxylesterase 1 (hCES1) is a major carboxylesterase in the human body and plays important roles in the metabolism of a wide variety of substances, including lipids and drugs, and therefore is attracting more and more attention from areas including lipid metabolism, pharmacokinetics, drug–dr...

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Detalles Bibliográficos
Autores principales: Yan, Maocai, Zhang, Zhen, Liu, Zhaoming, Zhang, Chunyan, Zhang, Jingchang, Fan, Shuai, Yang, Zhaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891567/
https://www.ncbi.nlm.nih.gov/pubmed/31717501
http://dx.doi.org/10.3390/molecules24224057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891567/
https://www.ncbi.nlm.nih.gov/pubmed/31717501
http://dx.doi.org/10.3390/molecules24224057

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