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Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry

Trace elements play an important role in the pathogenesis of several serious ophthalmological disorders, such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, cataract, etc. This study aimed to measure alterations of chemical elements’ (67) levels in the aqueous humor of pa...

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Autores principales: Dolar-Szczasny, Joanna, Święch, Anna, Flieger, Jolanta, Tatarczak-Michalewska, Małgorzata, Niedzielski, Przemysław, Proch, Jędrzej, Majerek, Dariusz, Kawka, Justyna, Mackiewicz, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891599/
https://www.ncbi.nlm.nih.gov/pubmed/31739645
http://dx.doi.org/10.3390/molecules24224127
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author Dolar-Szczasny, Joanna
Święch, Anna
Flieger, Jolanta
Tatarczak-Michalewska, Małgorzata
Niedzielski, Przemysław
Proch, Jędrzej
Majerek, Dariusz
Kawka, Justyna
Mackiewicz, Jerzy
author_facet Dolar-Szczasny, Joanna
Święch, Anna
Flieger, Jolanta
Tatarczak-Michalewska, Małgorzata
Niedzielski, Przemysław
Proch, Jędrzej
Majerek, Dariusz
Kawka, Justyna
Mackiewicz, Jerzy
author_sort Dolar-Szczasny, Joanna
collection PubMed
description Trace elements play an important role in the pathogenesis of several serious ophthalmological disorders, such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, cataract, etc. This study aimed to measure alterations of chemical elements’ (67) levels in the aqueous humor of patients undergoing cataract surgery. The pilot study included 115 patients, (age 74 ± 7.27, female 64.35%, male 35.65%). The aqueous levels of elements were measured by the use of the inductively coupled plasma optical emission spectrometry (ICP-OES), quality controlled with certified standards. The classification of elements based on their concentration was achieved by hierarchical cluster analysis. This is the first screening study that quantifies over 60 elements which are present in the fluid from the anterior chamber of the eye of cataract patients. The obtained results can be suitable for understanding and identifying the causes that may play a role in the initiation and progression of lens opacity.
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spelling pubmed-68915992019-12-12 Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry Dolar-Szczasny, Joanna Święch, Anna Flieger, Jolanta Tatarczak-Michalewska, Małgorzata Niedzielski, Przemysław Proch, Jędrzej Majerek, Dariusz Kawka, Justyna Mackiewicz, Jerzy Molecules Article Trace elements play an important role in the pathogenesis of several serious ophthalmological disorders, such as glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, cataract, etc. This study aimed to measure alterations of chemical elements’ (67) levels in the aqueous humor of patients undergoing cataract surgery. The pilot study included 115 patients, (age 74 ± 7.27, female 64.35%, male 35.65%). The aqueous levels of elements were measured by the use of the inductively coupled plasma optical emission spectrometry (ICP-OES), quality controlled with certified standards. The classification of elements based on their concentration was achieved by hierarchical cluster analysis. This is the first screening study that quantifies over 60 elements which are present in the fluid from the anterior chamber of the eye of cataract patients. The obtained results can be suitable for understanding and identifying the causes that may play a role in the initiation and progression of lens opacity. MDPI 2019-11-14 /pmc/articles/PMC6891599/ /pubmed/31739645 http://dx.doi.org/10.3390/molecules24224127 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dolar-Szczasny, Joanna
Święch, Anna
Flieger, Jolanta
Tatarczak-Michalewska, Małgorzata
Niedzielski, Przemysław
Proch, Jędrzej
Majerek, Dariusz
Kawka, Justyna
Mackiewicz, Jerzy
Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry
title Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry
title_full Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry
title_fullStr Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry
title_full_unstemmed Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry
title_short Levels of Trace Elements in the Aqueous Humor of Cataract Patients Measured by the Inductively Coupled Plasma Optical Emission Spectrometry
title_sort levels of trace elements in the aqueous humor of cataract patients measured by the inductively coupled plasma optical emission spectrometry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891599/
https://www.ncbi.nlm.nih.gov/pubmed/31739645
http://dx.doi.org/10.3390/molecules24224127
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