Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β(25-35) Self-Aggregation and Insulin Glycation: Elucidation of the Molecular Mechanism of Action

Both amyloid-β (Aβ) and insulin are amyloidogenic peptides, and they play a critical role in Alzheimer’s disease (AD) and type-2 diabetes (T2D). Misfolded or aggregated Aβ and glycated insulin are commonly found in AD and T2D patients, respectively, and exhibit neurotoxicity and oxidative stress. Th...

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Detalles Bibliográficos
Autores principales: Seong, Su Hui, Paudel, Pradeep, Jung, Hyun Ah, Choi, Jae Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891666/
https://www.ncbi.nlm.nih.gov/pubmed/31652867
http://dx.doi.org/10.3390/md17110600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891666/
https://www.ncbi.nlm.nih.gov/pubmed/31652867
http://dx.doi.org/10.3390/md17110600

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