Reduced Toxicity of Trichothecenes, Isotrichodermol, and Deoxynivalenol, by Transgenic Expression of the Tri101 3-O-Acetyltransferase Gene in Cultured Mammalian FM3A Cells

In trichothecene-producing fusaria, isotrichodermol (ITDol) is the first intermediate with a trichothecene skeleton. In the biosynthetic pathway of trichothecene, a 3-O-acetyltransferase, encoded by Tri101, acetylates ITDol to a less-toxic intermediate, isotrichodermin (ITD). Although trichothecene...

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Detalles Bibliográficos
Autores principales: Tanaka, Nozomu, Takushima, Ryo, Tanaka, Akira, Okada, Ayaki, Matsui, Kosuke, Maeda, Kazuyuki, Aikawa, Shunichi, Kimura, Makoto, Takahashi-Ando, Naoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891669/
https://www.ncbi.nlm.nih.gov/pubmed/31717667
http://dx.doi.org/10.3390/toxins11110654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891669/
https://www.ncbi.nlm.nih.gov/pubmed/31717667
http://dx.doi.org/10.3390/toxins11110654

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