[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors

Since hyperactivity of the protein kinase DYRK1A is linked to several neurodegenerative disorders, DYRK1A inhibitors have been suggested as potential therapeutics for Down syndrome and Alzheimer’s disease. Most published inhibitors to date suffer from low selectivity against related kinases or from...

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Detalles Bibliográficos
Autores principales: Lechner, Christian, Flaßhoff, Maren, Falke, Hannes, Preu, Lutz, Loaëc, Nadége, Meijer, Laurent, Knapp, Stefan, Chaikuad, Apirat, Kunick, Conrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891749/
https://www.ncbi.nlm.nih.gov/pubmed/31766108
http://dx.doi.org/10.3390/molecules24224090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891749/
https://www.ncbi.nlm.nih.gov/pubmed/31766108
http://dx.doi.org/10.3390/molecules24224090

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