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Dialkylation of Indoles with Trichloroacetimidates to Access 3,3-Disubstituted Indolenines
2-Substituted indoles may be directly transformed to 3,3-dialkyl indolenines with trichloroacetimidate electrophiles and the Lewis acid TMSOTf. These reactions provide rapid access to complex indolenines which are present in a variety of complex natural products and medicinally relevant small molecu...
Autores principales: | Suzuki, Tamie, Mate, Nilamber A., Adhikari, Arijit A., Chisholm, John D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891773/ https://www.ncbi.nlm.nih.gov/pubmed/31731742 http://dx.doi.org/10.3390/molecules24224143 |
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