Cargando…

Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer

BACKGROUND: Interleukin-6 (IL-6) is commonly highly secreted in the breast cancer (BrCA) microenvironment and implicated in disease development. In this study, we aimed to determine the role of the IL-6/pSTAT3/HIC1 axis in the breast cancer microenvironment, including in cancer-associated fibroblast...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Xueqing, Qu, Qing, Lao, Yimin, Zhang, Mi, Yin, Xiaoling, Zhu, Huiqin, Wang, Ying, Yang, Jie, Yi, Jing, Hao, Mingang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891969/ https://www.ncbi.nlm.nih.gov/pubmed/31795965 http://dx.doi.org/10.1186/s12885-019-6333-6

Ejemplares similares

IFI35 Promotes Renal Cancer Progression by Inhibiting pSTAT1/pSTAT6-Dependent Autophagy
por: Chai, Dafei, et al.
Publicado: (2022)

Expression of tSTAT3, pSTAT3(727), and pSTAT3 (705) in the epithelial cells of hormone‐naïve prostate cancer
por: Krzyzanowska, Agnieszka, et al.
Publicado: (2019)

Hypermethylated in cancer 1(HIC1) suppresses non-small cell lung cancer progression by targeting interleukin-6/Stat3 pathway
por: Wang, Xiumin, et al.
Publicado: (2016)

Small Activating RNA Restores the Activity of the Tumor Suppressor HIC-1 on Breast Cancer
por: Zhao, Feng, et al.
Publicado: (2014)

Direct targets of pSTAT5 signalling in erythropoiesis
por: Gillinder, Kevin R., et al.
Publicado: (2017)

Prognostic Significance of B-Cells and pSTAT3 in Patients with Ovarian Cancer
por: Yang, Chunmei, et al.
Publicado: (2013)

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53
por: Szczepny, Anette, et al.
Publicado: (2018)

Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth
por: Messaggio, Fanuel, et al.
Publicado: (2017)

Potential Refinement of Recurrence Score by pSTAT3 Status
por: Grinshpun, Albert, et al.
Publicado: (2022)

Impaired T-bet-pSTAT1α and perforin-mediated immune responses in the tumoral region of lung adenocarcinoma
por: Andreev, Katerina, et al.
Publicado: (2015)

Impaired T-bet-pSTAT1α and perforin-mediated immune responses in the tumoral region of lung adenocarcinoma
por: Andreev, Katerina, et al.
Publicado: (2016)

The assessment of correlation and prognosis among (18)F-FDG uptake parameters, Glut1, pStat1 and pStat3 in surgically resected non-small cell lung cancer patients
por: Kaida, Hayato, et al.
Publicado: (2018)

pSTAT1 Is Activated during the Progression of IgA Nephropathy
por: Tao, Jianling, et al.
Publicado: (2022)

AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages
por: Hung, Chia-Nung, et al.
Publicado: (2023)

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression
por: Wu, Tianqi, et al.
Publicado: (2022)

TLR4 and pSTAT3 Expression on Circulating Tumor Cells (CTCs) and Immune Cells in the Peripheral Blood of Breast Cancer Patients: Prognostic Implications
por: Papadaki, Maria A., et al.
Publicado: (2022)

The tumor suppressor function of STAT1 in breast cancer
por: Koromilas, Antonis E., et al.
Publicado: (2013)

Hypermethylation of HIC2 is a potential prognostic biomarker and tumor suppressor of glioma based on bioinformatics analysis and experiments
por: Luo, Feifei, et al.
Publicado: (2023)

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis
por: Pérez-Baos, Sandra, et al.
Publicado: (2019)

Dynamic Changes in pStat3 Are Involved in Meiotic Spindle Assembly in Mouse Oocytes
por: Haraguchi, Seiki, et al.
Publicado: (2020)

Sorafenib with ASC‐J9(®) synergistically suppresses the HCC progression via altering the pSTAT3‐CCL2/Bcl2 signals
por: Xu, Junjie, et al.
Publicado: (2016)

The clinical significance and underlying correlation of pStat-3 and integrin αvβ6 expression in gallbladder cancer
por: Enyu, Liu, et al.
Publicado: (2017)

Phosphorylated transducer and activator of transcription-3 (pSTAT3) immunohistochemical expression in paired primary and metastatic colorectal cancer
por: Marginean, Esmeralda C., et al.
Publicado: (2020)

BSCI-10. Invasive growth of brain metastases is driven by cancer cell-pSTAT3+ reactive astrocyte crosstalk
por: Dankner, Matthew, et al.
Publicado: (2021)

HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression
por: Du, Xuanling, et al.
Publicado: (2019)

NF-κB and pSTAT3 synergistically drive G6PD overexpression and facilitate sensitivity to G6PD inhibition in ccRCC
por: Zhang, Qiao, et al.
Publicado: (2020)

Correction to: NF-κB and pSTAT3 synergistically drive G6PD overexpression and facilitate sensitivity to G6PD inhibition in ccRCC
por: Zhang, Qiao, et al.
Publicado: (2020)

Hic-5 Remodeling of the Stromal Matrix Promotes Breast Tumor Progression
por: Goreczny, Gregory J., et al.
Publicado: (2016)

IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation
por: Lambert, Katharina, et al.
Publicado: (2022)

Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers
por: Moison, Céline, et al.
Publicado: (2014)

The focal adhesion scaffold protein Hic-5 regulates vimentin organization in fibroblasts
por: Vohnoutka, Rishel B., et al.
Publicado: (2019)

pSTAT3 Levels Have Divergent Expression Patterns and Associations with Survival in Squamous Cell Carcinoma and Adenocarcinoma of the Oesophagus
por: O’ Sullivan, Katie E., et al.
Publicado: (2018)

Immunohistochemical Features of MMP-9 and pSTAT1 in Granuloma Annulare and Sarcoidosis: A Comparative Study of 62 Cases
por: Wu, Ze, et al.
Publicado: (2023)

STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer
por: Lefler, Julia E, et al.
Publicado: (2022)

STAT1 is a sex‐specific tumor suppressor in colitis‐associated colorectal cancer
por: Crnčec, Ilija, et al.
Publicado: (2018)

Tumor Cells and Cancer-Associated Fibroblasts: A Synergistic Crosstalk to Promote Thyroid Cancer
por: Fozzatti, Laura, et al.
Publicado: (2020)

Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling
por: Fetoni, A R, et al.
Publicado: (2015)

Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling
por: Xu, Bao-Qing, et al.
Publicado: (2016)

Homocysteine induces mitochondrial dysfunction involving the crosstalk between oxidative stress and mitochondrial pSTAT3 in rat ischemic brain
por: Chen, Shuang, et al.
Publicado: (2017)

Formononetin Inhibits Progression of Endometriosis via Regulation of p27, pSTAT3, and Progesterone Receptor: In Vitro and In Vivo Studies
por: Park, Yunjeong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bbbq6foadnr2s5t8m6j2e9n8gl