Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies

We recently identified Secernin-1 (SCRN1) as a novel amyloid plaque associated protein using localized proteomics. Immunohistochemistry studies confirmed that SCRN1 was present in plaque-associated dystrophic neurites and also revealed distinct and abundant co-localization with neurofibrillary tangl...

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Detalles Bibliográficos
Autores principales: Pires, Geoffrey, McElligott, Sacha, Drusinsky, Shiron, Halliday, Glenda, Potier, Marie-Claude, Wisniewski, Thomas, Drummond, Eleanor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892024/
https://www.ncbi.nlm.nih.gov/pubmed/31796108
http://dx.doi.org/10.1186/s40478-019-0848-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892024/
https://www.ncbi.nlm.nih.gov/pubmed/31796108
http://dx.doi.org/10.1186/s40478-019-0848-6

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