Cargando…

The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo

BACKGROUND: While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the mechanisms regulating metastasis formation is essential to develop therapeutic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weber, Sarah, Koschade, Sebastian E., Hoffmann, Christopher M., Dubash, Taronish D., Giessler, Klara M., Dieter, Sebastian M., Herbst, Friederike, Glimm, Hanno, Ball, Claudia R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892194/ https://www.ncbi.nlm.nih.gov/pubmed/31796022 http://dx.doi.org/10.1186/s12885-019-6396-4

Ejemplares similares

Systematic Generation of Patient-Derived Tumor Models in Pancreatic Cancer
por: Ehrenberg, Karl Roland, et al.
Publicado: (2019)

Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer
por: Giessler, Klara M., et al.
Publicado: (2017)

The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation
por: Bodas, Manish, et al.
Publicado: (2021)

Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts
por: Ball, Claudia R, et al.
Publicado: (2017)

Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer
por: Brahim, Sonia, et al.
Publicado: (2023)

Colorectal cancer‐initiating cells caught in the act
por: Dieter, Sebastian M, et al.
Publicado: (2017)

Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL‐Dependent Manner
por: Sun, Hao, et al.
Publicado: (2023)

HEYL Regulates Neoangiogenesis Through Overexpression in Both Breast Tumor Epithelium and Endothelium
por: Han, Liangfeng, et al.
Publicado: (2021)

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle
por: Fukuda, Sumiaki, et al.
Publicado: (2019)

Partial-Methylated HeyL Promoter Predicts the Severe Illness in Egyptian COVID-19 Patients
por: Fadel, Hewida H., et al.
Publicado: (2022)

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells
por: Voloshanenko, Oksana, et al.
Publicado: (2013)

A comparative study of the capacity of mesenchymal stromal cell lines to form spheroids
por: Deynoux, Margaux, et al.
Publicado: (2020)

Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1
por: Veithen, Mona, et al.
Publicado: (2023)

Exosomal lncRNA SCIRT/miR-665 Transferring Promotes Lung Cancer Cell Metastasis through the Inhibition of HEYL
por: Wang, Zhengyang, et al.
Publicado: (2021)

Modulation of Spheroid Forming Capacity and TRAIL Sensitivity by KLF4 and Nanog in Gastric Cancer Cells
por: To, Han Thi Ngoc, et al.
Publicado: (2022)

The HeyL-Aromatase Axis Promotes Cancer Stem Cell Properties by Endogenous Estrogen-Induced Autophagy in Castration-Resistant Prostate Cancer
por: Lin, Qimei, et al.
Publicado: (2022)

Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment
por: Singh, Sandeep, et al.
Publicado: (2012)

Correction to: Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment
por: Singh, Sandeep, et al.
Publicado: (2020)

The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis
por: Tuorto, Francesca, et al.
Publicado: (2015)

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model
por: Klose, Johannes, et al.
Publicado: (2019)

Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer
por: Zowada, Martina K., et al.
Publicado: (2021)

Do mitochondria donate membrane to form autophagosomes or undergo remodeling to form mitochondrial spheroids?
por: Ding, Wen-Xing, et al.
Publicado: (2014)

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)(2) Containing Liposomes for the Treatment of Neuroblastoma
por: Hartwig, Friederike, et al.
Publicado: (2021)

Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors
por: Dieter, Sebastian M., et al.
Publicado: (2022)

Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats
por: Taldaev, Amir, et al.
Publicado: (2023)

Notch signaling regulates myogenic regenerative capacity of murine and human mesoangioblasts
por: Quattrocelli, M, et al.
Publicado: (2014)

Carbon Ion Irradiation Downregulates Notch Signaling in Glioma Cell Lines, Impacting Cell Migration and Spheroid Formation
por: Kumar, Vivek, et al.
Publicado: (2022)

Prostate epithelial cell lines form spheroids with evidence of glandular differentiation in three-dimensional Matrigel cultures
por: Lang, S H, et al.
Publicado: (2001)

Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening
por: Theodoraki, Maria A., et al.
Publicado: (2015)

Integrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls
por: Horak, Peter, et al.
Publicado: (2016)

Transforming Growth Factor Beta Receptor 2 (TGFBR2) Changes Sialylation in the Microsatellite Unstable (MSI) Colorectal Cancer Cell Line HCT116
por: Lee, Jennifer, et al.
Publicado: (2013)

3D spheroid culture enhances survival and therapeutic capacities of MSCs injected into ischemic kidney
por: Xu, Yong, et al.
Publicado: (2016)

Influence of Conditioned Media on the Re-Differentiation Capacity of Human Chondrocytes in 3D Spheroid Cultures
por: Klinder, Annett, et al.
Publicado: (2020)

Penetration of Nanobody-Dextran Polymer Conjugates through Tumor Spheroids
por: Bitsch, Peter, et al.
Publicado: (2023)

Testing chemotherapy efficacy in HER2 negative breast cancer using patient-derived spheroids
por: Halfter, Kathrin, et al.
Publicado: (2016)

Iron Oxide Nanoparticles Stimulates Extra-Cellular Matrix Production in Cellular Spheroids
por: Casco, Megan, et al.
Publicado: (2017)

Development of Spheroid-FPOP: An In-Cell Protein Footprinting Method for 3D Tumor Spheroids
por: Shortt, Raquel L., et al.
Publicado: (2023)

CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation
por: Sternemalm, Johan, et al.
Publicado: (2015)

Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification
por: Knipping, Friederike, et al.
Publicado: (2017)

The response of gingiva monolayer, spheroid, and ex vivo tissue cultures to collagen membranes and bone substitute
por: Janjić, Klara, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_m46kdfofdrvv3svh6r9komj3vf