The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer’s disease

An impairment of amyloid β-peptide (Aβ) clearance is suggested to play a key role in the pathogenesis of sporadic Alzheimer’s disease (AD). Amyloid degradation is mediated by various mechanisms including fragmentation by enzymes like neprilysin, matrix metalloproteinases (MMPs) and a recently identi...

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Detalles Bibliográficos
Autores principales: Kirabali, Tunahan, Rigotti, Serena, Siccoli, Alessandro, Liebsch, Filip, Shobo, Adeola, Hock, Christoph, Nitsch, Roger M., Multhaup, Gerhard, Kulic, Luka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892233/
https://www.ncbi.nlm.nih.gov/pubmed/31796114
http://dx.doi.org/10.1186/s40478-019-0846-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892233/
https://www.ncbi.nlm.nih.gov/pubmed/31796114
http://dx.doi.org/10.1186/s40478-019-0846-8

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