mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

Sensing nutrient availability is essential for appropriate cellular growth, and mTORC1 is a major regulator of this process. Mechanisms causing mTORC1 activation are, however, complex and diverse. We report here an additional important step in the activation of mTORC1, which regulates the efflux of...

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Detalles Bibliográficos
Autores principales: Beaumatin, Florian, O’Prey, Jim, Barthet, Valentin J.A., Zunino, Barbara, Parvy, Jean-Philippe, Bachmann, Alexis Maximilien, O’Prey, Margaret, Kania, Elżbieta, Gonzalez, Pablo Sierra, Macintosh, Robin, Lao, Laurence Y., Nixon, Colin, Lopez, Jonathan, Long, Jaclyn S., Tait, Stephen W.G., Ryan, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892261/
https://www.ncbi.nlm.nih.gov/pubmed/31492633
http://dx.doi.org/10.1016/j.molcel.2019.07.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892261/
https://www.ncbi.nlm.nih.gov/pubmed/31492633
http://dx.doi.org/10.1016/j.molcel.2019.07.021

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