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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
Sensing nutrient availability is essential for appropriate cellular growth, and mTORC1 is a major regulator of this process. Mechanisms causing mTORC1 activation are, however, complex and diverse. We report here an additional important step in the activation of mTORC1, which regulates the efflux of...
Autores principales: | Beaumatin, Florian, O’Prey, Jim, Barthet, Valentin J.A., Zunino, Barbara, Parvy, Jean-Philippe, Bachmann, Alexis Maximilien, O’Prey, Margaret, Kania, Elżbieta, Gonzalez, Pablo Sierra, Macintosh, Robin, Lao, Laurence Y., Nixon, Colin, Lopez, Jonathan, Long, Jaclyn S., Tait, Stephen W.G., Ryan, Kevin M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892261/ https://www.ncbi.nlm.nih.gov/pubmed/31492633 http://dx.doi.org/10.1016/j.molcel.2019.07.021 |
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